Preimplantation genetic testing is a complex technique in which an embryo is tested for a specific known genetic condition or a chromosome variation. This form of testing allows only genetically healthy embryos, or those not affected by specific genetic conditions, to be selected for transfer into the IVF cycle. All of this in turn maximizes the chances of a healthy baby.
There are many variations of preimplantation genetic testing PGT. Some of the most common ones are as follows:
Although just about anyone can do the preimplantation genetic testing treatment in Nepal, this testing is ideal for specific patients. Some of the types of patients for whom preimplantation genetic testing PGT is highly suitable are as follows:
In the process of preimplantation genetic testing, you or your partner go through a standard IVF cycle. Then, a few cells are removed from each embryo and tested in two ways. This testing is conducted while the embryos are developing in the preimplantation genetic testing IVF laboratory.
The two ways on how the embryos are tested are as follows:
This technique tests a complete set of 24 chromosomes in an embryo to enable the selection and transfer of healthy embryos.
This process is used if you and/or your partner carry one or more serious single-gene disorders. This process can identify the embryos that are not affected by the specific disorder. This, in turn, prevents the conditions from being passed on to the next generation.
As its name implies, preimplantation genetic testing can be used to test disorders and diseases associated with genetics. This testing includes testing for diseases that may lead to abnormal babies, issues with successful birth, or miscarriage. Furthermore, with the current technology, PGT treatment in Nepal can identify over 20,000 genetic mutations that can cause the mentioned problems.
The core focus of this testing is based on genes. Therefore, this testing cannot identify diseases and problems not associated with genes.
Chromosomal variation refers to changes in or differences in the structure or the number of chromosomes from the normal chromosome set. Normally, every cell in an embryo should have 46 chromosomes arranged in 23 pairs if there are any missing or extra chromosomes. This is called "aneuploidy," and it includes conditions such as Down syndrome.
This form of disorder can affect up to 70% of the early human embryos, leading them to stop developing.
Yes, it can. A chromosomal translocation is a genetic condition in which one or more pieces of chromosomes are exchanged or linked.
It should be noted that only 2% of people with reproductive problems have balanced translocation. This condition is where a chromosome is rearranged, but there is an overall correct amount of genetic material. Therefore, the person is completely healthy.
In this situation, some eggs or sperm can have the wrong amount of genetic material. It further leads to the embryo having an unbalanced translocation. These embryos have a high chance of miscarriage. Even if the child is born, they have a high chance of having severe health problems.
Therefore, PGT can detect the case of a balanced translocation or any form of chromosomal translocation Next Generation Sequencing.
You can use PGT to determine the exact genetic error that causes gender-associated disease. However, using PGT specifically for gender selection is not allowed.
No, preimplantation genetic testing (PGT) does not harm or damage the embryo when done correctly. Although during the PGT testing in Nepal, the experts remove some cells from the outer layer of the embryo, it does not cause any harm to the embryo.
Just like with any other medical procedure, the PGT treatment in Nepal has its share of benefits and risks. Some of the preimplantation genetic testing pros and cons are as follows:
The specifics of IVF with genetic testing success rates will vary depending on your circumstances. However, in general, this procedure has been shown to increase the rates by 10% to 15% compared to IVF alone.
The specific cost of PGT treatment in Nepal will vary depending on the number of embryos. That said, the cost on average is NPR 30,000 per embryo in Nepal.
Some of the risks of preimplantation genetic testing include embryo loss, false results, and multiple pregnancies.
Yes, preimplantation genetic testing is worth the cost and effort if you or your partner has some genetic disorders that can be passed through the genes. Furthermore, it is also ideal for detecting any forms of disorders in the genes of the embryo, ensuring a safe and healthy childbirth.
There are many categories of couples who can benefit from PGT. Some of these include the following:
The specific cost of PGT in Nepal varies depending on the number of embryos. The average cost is NPR 30,000 per embryo in Nepal.
PGT is generally recommended for those with:
PGT involves the process of ovarian stimulation, egg retrieval, fertilization, and embryo culture to the blastocyst stage. At days 5-6, several trophectoderm cells are biopsied from embryos. Cells are then analyzed using FISH, PCR, microarray, or NGS to detect chromosomal abnormalities and/or genetic mutations. Then, the unaffected embryos can be selected for transfer or freezing.