Difference Between IVF and ICSI.
Mar 2024 Admin
IVF

What is the Difference Between IVF and ICSI?

Infertility used to be a huge issue in the past. However, in modern times, there are many techniques and assisted reproductive treatments that can aid you. That said, deciding to go through assisted reproductive treatment is by no means an easy process. There are many treatment-assisted reproduction treatment options available for you. Among many such treatments, two of the most popular ones are in vitro fertilization (IVF) and Intracytoplasmic Sperm Injection (ICSI). Unless you work closely with these treatments, they may seem the same for you. So the question is, "What is the difference between IVF and ICSI?

In this blog, we discuss the difference between IVF and ICSI treatment. So, with this in mind, let's get started. 

What are IVF and ICSI?

IVF and ICSI are both different forms of assisted reproductive treatments. This is where the key similarities between IVF and ICSI end. 

IVF: Introduction 

The "In vitro" refers to "in glass". Therefore, in vitro fertilization (IVF) is a process where eggs are fertilized and developed inside a laboratory dish. 

ICSI:  Introduction

On the other hand, Intracytoplasmic Sperm Injection (ICSI) is a technique used in assisted reproductive treatment as a part of IVF. In this process, the experts directly inject sperm into the egg. 

What are The Difference Between IVF and ICSI?

Beautiful fertility concept considering in vitro fertilization.

Although both IVF and ICSI are assisted reproductive treatments, there are some key differences between these two. From the definition mentioned above, you should already have a general idea of these two procedures. That said, besides the definition, these two have other differences. These differences are as follows:

Difference IVF ICSI
Process 1. Ovulation Induction
2. Egg Retrieval
3. Fertilization
4. Embryo Culture
5. Embryo Transfer
6. Luteal Phase Support
1. Ovulation Induction
2. Egg Retrieval
3. ICSI Process
4. Embryo Culture
5. Embryo Transfer
Success Rates The overall success rate of IVF in Nepal is between 70% to 80%. The overall success rate of ICSI is between 50% to 80% in Nepal. 
Benefits Ideal for women over 35 with low ovarian reserve and female patients with a wide range of health conditions. Ideal for men with low sperm count or issues with sperm motility. 
Cost The cost of IVF in Nepal is between NPR 2,50,000 and NPR 4,00,000. The cost of ICSI in Nepal is between NPR 3,50,000 and Npr 4,00,000.

 

The Difference between IVF vs ICSI Process: IVF vs ICSI

One of the key ICSI and IVF difference is the process involved in these procedures. The process of IVF and ICSI are as follows:

Process of In vitro fertilization (IVF)

There are six key steps involved in the process of IVF. They are as follows:

1) Ovulation Induction

In this step, the female patient is given medications to stimulate her ovaries and produce multiple eggs.

2) Egg Retrieval

Once the eggs are mature, they are retrieved from the ovaries using a minor surgical process.

3) Fertilization

The retrieved eggs are then fertilized inside a petri dish.

4) Embryo Culture

After fertilizing the eggs, they are left to culture for three to five days. This process lasts three to five days, depending on the specifics of the circumstances. 

5) Embryo Transfer

After the embryo reaches a specific stage, they are transferred back into the female patient's uterus. 

6) Luteal Phase Support

The reproductive expert then provides female patients with hormonal medications to support the uterine lining and increase the chances of successful implantation. 

Process of Intracytoplasmic Sperm Injection (ICSI) 

Beautiful fertility concept.

You can divide the entire process of ICSI treatment in Nepal into five key steps. The steps involved in the Intracytoplasmic Sperm Injection (ICSI) process are as follows:

1) Ovulation Induction

In this process, the female process goes through an ovarian stimulation process. The experts provide them with medicines to produce multiple eggs. 

2) Egg Retrieval

The mature eggs are then retrieved from the female patient's ovaries using a minor surgical process. 

3) ICSI Process

Rather than allowing the sperm to fertilize the egg naturally, experts inject a single healthy sperm directly into the cytoplasm of the egg. 

4) Embryo Culture

In this process, the fertilized egg is left for development into the embryo in a laboratory dish. 

5) Embryo Transfer

Once the embryos reach a particular stage, one or more healthy embryos are selected and transferred into the female patient's uterus. 
These are the general processes involved in the IVF and ICSI processes. As you may have noticed, the key difference between the process of IVF and ICSI is in the fertilization state. 

Success Rates: IVF vs ICSI

Ovum with a needle showing in vitro fertilization concept.

Another key difference between IVF and ICSI is in their success rates. While the general process and steps remain the same, the success rate is indeed different. The overall success rate of IVF in Nepal is between 70% and 80%. At the same time, the overall success rate of ICSI is between 50% to 80% in Nepal

Benefits: IVF vs ICSI

Now that we know the process and success rates of IVF and ICSI treatment let's talk about the key benefits of IVF and ICSI treatments. They are as follows:

Benefits of IVF Treatment

  • Better fertilization and implantation rates.
  • Can help female patients with a wide range of health conditions including but not limited to endometriosis, ovulation disorders, damaged fallopian tubes and polycystic ovary syndrome (PCOS).
  • Ideal for women over 35 with low ovarian reserve.
  • Can help couples with unexplained fertility problems.
  • Enables couples to control their pregnancy.
  • It can be used with donated sperm or eggs. 

Benefits of ICSI treatment

  • Higher fertilization rate for couples with male infertility.
  • Increased number of fertilized eggs from one egg collection.
  • Ideal for men with low sperm count or issues with sperm motility.
  • Suitable for men with sperm development problems.
  • Ideal for men with ejaculation blockages.
  • It can help couples time their pregnancy.
  • It can be done with donated sperm or eggs. 

Risks: IVF vs ICS

As with all forms of medical procedures, both IVF and ICSI treatment also have their fair share of risks. While the benefits do outweigh the risks by several folds, we cannot ignore this aspect. Some of the key risks associated with IVF and ICSI are as follows:

Ovum with a needle showing in vitro fertilization treatment concept.

Risks of IVF

  • Slight risk of premature delivery
  • Small risk of multiple births
  • Ovarian hyperstimulation syndrome (OHSS)
  • Complications in egg collection
  • Ectopic pregnancy 

Risks of ICSI

  • Slight chance of a damaged egg.
  • Risk of having a baby with a chromosomal abnormality in the X or Y chromosomes.

Do note that the risks for both IVF and ICSI are relatively small. Regardless, we still need to consider these differences in risks in IVF and ICSI when considering these treatments. 

Cost: IVF vs ICSI

Although the costs of both IVF and ICSI are somewhat similar, there is a slight difference. The cost of IVF in Nepal is between NPR 2,50,000 and NPR 4,00,000. On the other hand, the cost of ICSI in Nepal is between NPR 3,50,000 and Npr 4,00,000.

As you may notice, the ending price range for both of these procedures is the same. The cost difference between IVF and ICSI is in the starting cost. 

Which One is Better, IVF or ICSI?

Which one is better, IVF or ICSI.

There is no definitive answer to this question. Depending on the specifics of your circumstances, any one of these two options may be better for you. However, there are some general considerations you can make. These considerations are as follows:

  • ICSI has a higher success rate for male infertility, while IVF has a higher rate in general.
  • ICSI typically has a higher fertility rate when compared to IVF.
  • ICSI poses a slightly higher risk of egg damage.
  • ICSI is a bit more expensive than IVF in general.
  • The risks of birth with birth effects are slightly higher in ISCI when compared to IVF. 

In general, IVF is considered a general approach, while ICSI is taken as a more specific approach. If there are no male fertility issues, you should consider IVF before ICSI. However, if there is male infertility in question, then ICSI is typically considered better for you. 

Conclusion 

Both IVF and ICSI are relatively popular forms of assisted reproductive treatments. That said, there are a few key differences in their procedures. IVF is an overall process, while ICSI is considered a part of IVF. Besides the procedures, there are key differences in their benefits, risks, and costs. That said, there is no clear "better" one. Both of these treatments have their area of effect. 

In this blog, we discussed the key differences between IVF and ICSI. We hope you found this helpful. If you want further insights into IVF and other fertility services, check out some of our other blogs. If you want the best IVF and ICSI treatment in Nepal, feel free to contact us at Hardik IVF and Fertility- The best IVF Center in Nepal. Thank you for reading till the end. 

FAQs on The Difference Between IVF and ICSI

What is the percentage of ICSI success?

ICSI success rate is usually between 50% and 80% on the eggs performed. That said, the specifics can vary depending on your circumstances. 

What is the success rate of IVF in Nepal?

The success rates for IVF in Nepal are between 70% and 80%

Is ICSI more successful than IVF?

ICSI has a better success rate when it comes to male infertility, while IVF has a better success rate in general. 

What is the difference between IVF and ICSI?

The key difference between IVF and ICSI is IVF is a process where eggs are fertilized and developed inside a laboratory dish. Moreover, ICSI is a technique used in assisted reproductive treatment as a part of IVF.

Is ICSI more expensive than IVF?

While the end cost for IVF and ICSI are both the same, the starting price of ICSI is indeed higher than that of IVF. 

Can IVF be done without ICSI?

Yes, you can conduct IVF without ICSI treatment.

What is better IVF or ICSI?

There is no clear answer to which is better between IVF and ICSI. IVF is a better treatment in general while ICSI is relatively better for mild-male-factor infertility. 

What are the benefits of ICSI over IVF?

The benefits of ICSI over IVF are as follows:

  • Higher fertilization rate.
  • Less risk of total fertilization failure in male factor infertility.
  • Increased number of high-quality fertilized eggs from one egg cycle.

Is ICSI 100% successful?

No, it is not. Although ICSI has a high success rate, especially for male-factor infertility, it is not 100% successful. 

Does ICSI lead to twins?

There is a small risk of ICSI leading to twins. However, the chances are similar to that of regular pregnancy.